Nadaljuj poved

[AlterMann]

virtualno hvala nazaj, nazaj v mozirski gaj

[Tabo]

pa pojdimo na en :beer2:

[bmwslo]

takoj zdaj

[Tabo]

v najbližji lokal

[AlterMann]

je rekel tolovaj mataj

[Tabo]

po 3 perih seveda

[bmwslo]

ko je bil nadevan kot zmaj

[AlterMann]

saj že štiri mesce praznuje 1. maj

[bmwslo]

in je tik pred odhodom v raj

[Medoo]

zato je vzel pivo za vsak slučaj

[riderrgirl]

s sabo na zdravljenje..v obljubljeni raj

[Tabo]

kjer vecno bomo skupaj

[AlterMann]

ti in jaz pa oliva in popaj

[Tabo]

pa se kdo bi se najdu

[riderrgirl]

da bi bila družba bl popolna

[Tabo]

povabili bi še par deklet

[riderrgirl]

da nebi bli tako zapet

[Tabo]

povabim še tebe da greva odpet

[KeC]

Monocyte chemoattractant protein-1 (MCP-1) is a potent agonist for mononuclear leukocytes and has been implicated in the pathogenesis of atherosclerosis and granulomatous lung disease. To determine the role of MCP-1 and related family members in vivo, we used homologous recombination in embryonic stem cells to generate mice with a targeted disruption of C-C chemokine receptor 2 (CCR2), the receptor for MCP-1. CCR2-/- mice were born at the expected Mendelian ratios and developed normally. In response to thioglycollate, the recruitment of peritoneal macrophages decreased selectively. In in vitro chemotaxis assays, CCR2-/- leukocytes failed to migrate in response to MCP-1. Granulomatous lung disease was induced in presensitized mice by embolization with beads coupled to purified protein derivative (PPD) of Mycobacterium bovis. As compared with wild-type littermates, CCR2-/- mice had a decrease in granuloma size accompanied by a dramatic decrease in the level of interferon gamma in the draining lymph nodes. Production of interferon gamma was also decreased in PPD-sensitized splenocytes from CCR2-/- mice and in naive splenocytes activated by concanavalin A. We conclude that CCR2-/- mice have significant defects in both delayed-type hypersensitivity responses and production of Th1-type cytokines. These data suggest an important and unexpected role for CCR2 activation in modulating the immune response, as well as in recruiting monocytes/macrophages to sites of inflammation.

[riderrgirl]

bomo si eno odpel ja..da

[Tabo]

pova valček zaplesala

[riderrgirl]

se bova zasukala....

[Tabo]

dokler ne podvodni mož pride

[riderrgirl]

dokler ne podvodni mož pride

pa js zginem....ampak pridejo pa ostali...

[Tabo]

skočim v vodo in te rešim